Tumor suppressor prostaglandin D2
نویسندگان
چکیده
منابع مشابه
Tumor suppressor prostaglandin D2
Colorectal cancer is the cause of death for some 600,000 people per year in the world and patient numbers are still increasing. Risk of colorectal cancer is greatly increased by inherited factors, lifestyle (smoking or alcohol consumption) and microbial infections causing bowel inflammation (colitis). The prolongation of colitis leads to tumorigenesis. The mechanism by which chronic colitis dev...
متن کاملRole of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo.
Although COX-dependent production of prostaglandins (PGs) is known to be crucial for tumor angiogenesis and growth, the role of PGD(2) remains virtually unknown. Here we show that PGD(2) receptor (DP) deficiency enhances tumor progression accompanied by abnormal vascular expansion. In tumors, angiogenic endothelial cells highly express DP receptor, and its deficiency accelerates vascular leakag...
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When PGD2 was topically applied to the rabbit eye a reduction of intraocular pressure (IOP) was observed within 30 min. The IOP reduction lasted throughout the observation period of 7 hours. No increase of IOP was observed during the period. The effect of PGD2 was dose-dependent (0.4 microgram to 250 micrograms), and the minimum effective dose was estimated to be 2.0 micrograms. The application...
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Fibroblasts play an important role in the repair and remodelling processes following injury. Prostaglandin D2 (PGD2) is a potent mediator in inflammatory processes. In this study, the effect of the PGD2 on human foetal lung fibroblasts (HFL-1) chemotaxis induced by human plasma fibronectin (HFn) was investigated using the blindwell chamber technique. PGD2 inhibited HFL-1 chemotaxis to HFn (20 m...
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were concentration-dependently relaxed by PGD2 (0.01-1 ,uM), a reaction that was blocked by a selective PGD receptor antagonist (BW A868C). There was a tight correlation between PGD2and acetylcholineinduced relaxations (r=0.894, n=96, p<0.001). Removal of endothelium abolished the PGD2-induced relaxation and unmasked a contractile activity of the compound. Inhibition of endogenous PGI2 formatio...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2014
ISSN: 2331-4737
DOI: 10.18632/oncoscience.53